The synthesis of carbonyl 2-amino-pyrimidines via tandem regioselective heterocyclization of 1,3-diynes with guanidine and selective oxidation.

نویسندگان

  • Liang Zhang
  • Mingzhu Zhao
  • Xiaoming Zhao
چکیده

A highly efficient one-pot approach for the synthesis of carbonyl 2-amino-pyrimidines from 1,3-diynes and guanidine in the presence of Cs2CO3 and DMSO has been described. In these reactions, 1,3-diynes act as a precursor of buta-1,2,3-trienes and guanidine serves as the N-C[double bond, length as m-dash]N source for the construction of pyrimidines. This methodology proves to be a tandem regioselective heterocyclization of 1,3-diynes with guanidine and selective oxidation with DMSO.

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عنوان ژورنال:
  • Chemical communications

دوره 51 45  شماره 

صفحات  -

تاریخ انتشار 2015